The PRS Custom 22 is an Electric Guitar used by John Mayer.

The PRS Custom 22 is an electric guitar known for its midrange and clarity, largely due to its 85/15 pickups, which are wired to a 5-way blade switch for various tonal options, including a dual humbucker setting. It features a solid mahogany neck and a PRS patented Gen III tremolo system. The guitar’s body consists of a carved figured maple top and a mahogany back. Its rosewood fretboard is adorned with PRS’s signature bird inlays.